Table 2 Serum concentrations of PFASs and PFAS precursors, associations and ratios between matched maternal and cord serum.

From: Placental Transfer of Perfluoroalkyl Substances and Associations with Thyroid Hormones: Beijing Prenatal Exposure Study

 

PFHxS (ng/mL)

PFOS (ng/mL)

PFOA (ng/mL)

PFNA (ng/mL)

PFDA (ng/mL)

PFUnA (ng/mL)

PFDoA (ng/mL)

6:2 FTS (pg/mL)

NMeFOSAA (pg/mL)

Maternal serumab

 Percent > LOD

100%

100%

100%

100%

100%

99%

68%

82%

74%

 Mean ± SD

0.63 ± 0.47

5.08 ± 3.26

1.95 ± 1.09

0.52 ± 0.27

0.45 ± 0.28

0.45 ± 0.24

0.046 ± 0.026

48.38 ± 40.94

4.77 ± 6.68

 Median

0.50

4.41

1.64

0.46

0.37

0.40

0.041

41.44

3.40

 GM

0.53

4.23

1.74

0.46

037

0.38

0.040

26.04

2.06

 Range

0.12–4.22

0.73–19.96

0.73–8.11

0.13–1.69

0.038–2.07

<LOD-1.27

<LOD-0.15

<LOD-203.00

<LOD-46.79

Cord serumab

 Percent > LOD

100%

100%

100%

100%

100%

96%

33%

90%

66%

 Mean ± SD

0.26 ± 0.30

1.52 ± 1.01

1.32 ± 0.69

0.23 ± 0.12

0.13 ± 0.09

0.14 ± 0.10

0.028 ± 0.013

33.54 ± 38.52

1.58 ± 2.36

 Median

0.18

1.18

1.15

0.20

0.10

0.12

0.021

24.68

0.67

 GM

0.19

1.27

1.18

0.21

0.10

0.11

0.026

19.98

0.76

 Range

0.014–3.17

0.24–6.93

0.40–5.06

0.05–0.80

0.024–0.61

<LOD-0.75

<LOD-0.082

<LOD-252.12

<LOD-16.00

 Maternal-fetal correlationc

r = 0.684 P < 0.001

r = 0.626 P < 0.001

r = 0.806 P < 0.001

r = 0.704 P < 0.001

r = 0.652 P < 0.001

r = 0.630 P < 0.001

r = 0.520 P < 0.001

r = 0.336 P < 0.001

r = 0.399 P < 0.001

Maternal and cord serum concentration ratiod

 Mean CS ± SD:MS

0.43 ± 0.34:1

0.36 ± 0.35:1

0.71 ± 0.22:1

0.49 ± 0.29:1

0.35 ± 0.44:1

0.36 ± 0.42:1

0.61 ± 0.34:1

3.08 ± 4.34:1

7.79 ± 11.14:1

 Median CS:MS

0.35:1

0.29:1

0.65:1

0.43:1

0.25:1

0.27:1

0.51:1

1.66:1

3.83:1

  1. LOD, limit of detection; SD, standard deviation; GM, geometric mean; CS, Cord Serum; MS, Maternal Serum. aUndetectable concentration was accounted as a value equal to the LOD divided by the square root of 2 and values below the LOQ were used unaltered. bData of other analyates were not reported due to the low frequency of detection in the samples (<30% in both maternal and cord serum samples). cSince concentrations of PFHxS, PFOS, PFOA, PFNA, PFDA and PFUnA were normally distributed after log-transformed, Pearson correlation test was used to test the log-transformed concentrations for possible correlations. Spearman correlation test was used to test the correlations of non-normally distributed PFDoA, 6:2 FTS and NMeFOSAA. dFor each compound, samples having undetectable concentration in both maternal and cord serum were excluded.
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