Figure 2: Apigenin inhibited melanoma cell migration and invasion.

(A) A single scratch was created in the confluent monolayer of A375, G361 or B16F10 cells. The scratch was photographed at 0 h and 24 h after treatment with the indicated concentrations of apigenin (upper) and relative migrated areas (bottom) were analyzed by Image J software. (B) A375, G361 or B16F10 cells were treated with indicated concentrations of apigenin for 16 h, and the invasive capacity was determined by the Transwell invasion assay. Representative photographs of invasive cells (left) and quantification of invasive cells (right) were shown. Data were mean ± SD from three independent experiments, *P < 0.05 and **P < 0.01.