Figure 2: ULK1 is required for resveratrol-induced autophagy.
From: Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition
(A) Autophagy induction by resveratrol (50 μM, 2 h) in the presence or absence of ULK1. Lenti virus encoding vector or shULK1 was introduced into GFP-LC3 expressing HeLa cells. (B) Autophagy induction by resveratrol (50 μM, 2 h)in the presence or absence of ULK1. cDNA encoding vector or shULK1 was transfected into HEK293 cells. Scale bars in fluorescent pictures represent 20 μm. (C) Autophagy induction by H-89 (10 μM, 2 h) in the presence or absence of ULK1. cDNA encoding vector or shULK1 was transfected into HEK293 cells.
