Figure 3: Histopathologic and ultrastructural features of the proband’s skin lesion.
From: A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome
Hematoxylin and eosin (H&E) of the skin lesion indicated psoriasiform hyperplasia with compact hyperkeratosis, acanthosis, the lower layers of corneum and epidermis significant parakeratosis, hypogranulosis with vesicular degeneration (a,b); Elcetron microscope demonstrated large coarse densely packed bundles of tonofilaments in the keratinocytes of the midmalpighian layer and increased numbers of the coarse keratinohyaline granules in the granular layer. Decreased numbers of chromocytes and pigment granules. The langerhans cells are absent (c,d).
