Figure 5
Pathological changes in the lungs of the inoculated pigs.
(A) H&E and IHC examinations were performed on the lungs of pigs at 5 dpi. Solid arrows indicate edema of the bronchial and vessel walls around inflammatory cells, including lymphocytes and monocytes; triangle indicates desquamation of epithelial cells of the mucous membrane and diffuse infiltration of neutrophils and alveolar macrophages in the bronchial lumen. Open arrows show that SIV-positive signals were detected in the lungs of infected piglets. Scale bar, 200 μm. (B,C) Scores of microscopic lesions (B) and SIV-positive signals (C) in lungs were evaluated blinded by two independent pathologists. Data are presented as means ± SD of three independent pigs. *the value was significantly different from that of Sw-61X (P < 0.05, ANOVA).
