Figure 9 | Scientific Reports

Figure 9

From: Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis

Figure 9

Schematic representation of the mechanism of action of CuB against the metastatic abilities of NSCLC.

CuB inhibits the expression of canonical Wnt ligands, which leads to the degradation or inactivation of β-catenin. This results in the reduction of nuclear translocation of β-catenin leading to inhibition of metastasis and angiogenesis.

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