Table 3 Brain regions with significantly higher GC values from and to right ORBmid in MDD compared with HC.

From: Causal connectivity alterations of cortical-subcortical circuit anchored on reduced hemodynamic response brain regions in first-episode drug-naïve major depressive disorder

Region name

C

Coordinates

Peak t-value

Abbr.

Hem

X

Y

Z

CS

Outgoing

 Frontal

Medial frontal gyrus, orbital

ORBmed

R

3

51

−3

151

4.72

 Limbic

Anterior cingulate cortex

ACC

L

−12

42

6

117

4.16

Incoming

 Frontal

Superior frontal gyrus

SFG

L

−18

12

66

161

2.88

Medial frontal gyrus, orbital

ORBmed

L

−48

51

−3

112

3.10

Inferior frontal gyrus, triangular

IFGtri

L

−57

24

18

209

4.04

Inferior frontal gyrus, opercular

IFGoper

L

−60

21

33

93

4.65

 Limbic

Middle temporal gyrus, temporal pole

MTGp

L

−42

9

−27

51

3.21

Middle cingulate gyrus

MCG

L

−9

6

42

104

3.03

  

R

9

21

36

44

2.82

  1. Hem: Hemisphere; CS: Cluster size.