Figure 2: Molecular network of disparate evolutionary species is structurally and functionally related. | Scientific Reports

Figure 2: Molecular network of disparate evolutionary species is structurally and functionally related.

From: New strategy for drug discovery by large-scale association analysis of molecular networks of different species

Figure 2

(a) Heat map of cross-species module chemico-biological similarity (MChS) matrix among 86 human modules (columns) and 13,023 plant/microbe modules (rows). Each dot in row i and column j represents MChS score between a plant/microbe module (row i) and a human module (column j). Color code represents MChS scores indicating the degree of chemico-biological similarity of two modules. (b) Four MChS score box plots for human, plants, fungi, and bacteria modules. Boxes represent the interquartile range (IQR) between first and third quartiles of MChS scores. Whiskers denote lowest/highest values within 1.5 × IQR from the first and third quartiles, respectively. Red dots represent outliers beyond the whiskers. The red line in each box plot represents MChS score means. The bottom table shows the top 10 human, plants, fungi and bacteria modules with the highest mean MChS scores. (c) Chemico-biological association degree of 267 organisms in plant/microbe with human. Association degree is quantified as the ratio of high chemico-biologically similar module pairs (MChS > 0.6) to all module pairs between each organism in plant/microbe and human. The bottom table shows the top 20 plants, fungi and bacteria with the highest chemico-biological association degree with human, respectively. Inset shows ratio distributions. P-values indicate statistical significance of the difference of the average ratios (Student’s t-test).

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