Figure 3: Natural chemical molecules from disparate evolutionary species show similar biological functions. | Scientific Reports

Figure 3: Natural chemical molecules from disparate evolutionary species show similar biological functions.

From: New strategy for drug discovery by large-scale association analysis of molecular networks of different species

Figure 3

(a) Chemical similarity between natural product (NP) sets (columns) and drug sets (rows) from plant/microbe and human modules. Each dot in row i and column j represented chemical structure similarity between a drug set (row i) and a NP set (column j). Color code represents chemical similarity scores indicating the degree of similarity of two compound sets. (b) Drug-likeness evaluation for NPs related plant/microbe modules. (c) Proportion of NP-derived drugs to all drugs related to each human module. (d) Potential of an organism in plant/microbe to produce drug-like NPs. (e) ATC classification for drugs and predicted ATC classification for NPs. (f) Distribution of chemical similarity score between NP and drug sets, and the proportion of NP and drug sets that have significant ATC similarities (green part).

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