Figure 5: Plant HA cycle related nature chemicals modulate the human Nrf2-ARE module. | Scientific Reports

Figure 5: Plant HA cycle related nature chemicals modulate the human Nrf2-ARE module.

From: New strategy for drug discovery by large-scale association analysis of molecular networks of different species

Figure 5

(a) Illustration of the chemico-biological similarity between plant HA cycle and the human Nrf2-ARE module. (b) Structure similarity between chemicals related to plant HA cycle and human Nrf2-ARE module. (c) Nuclear Nrf2 increased with resveratrol and α-viniferin. (d) Quantitative RT-PCR confirmation of induction of key downstream genes of the Nrf2-ARE pathway (GCLC, GCLM, GST, SOD and NQO1). (e) Cellular glutathione (GSH) and reactive oxygen species (ROS) increased with resveratrol and α-viniferin compared with controls. *, #, +indicate p < 0.05; **, ##, ++indicate p <0.01 (two-tailed Student’s t-test; n ≥ 3). Errors bars are standard deviations of measurements.

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