Figure 1 | Scientific Reports

Figure 1

From: Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery

Figure 1

Characteristics of MSNs and ICG/MSNs-RGD and RGD-mediated tumour specificity in vivo.

(A) TEM image of MSNs showing a typical spherical structure and average particle size. The inset shows the particle size distribution of ICG/MSNs-RGD. Scale bar, 100 nm. (B) SEM image of MSNs confirmed the TEM findings in (A). In vivo continuous observations (120 h) of liver cancer xenografts after administration of ICG/MSNs-RGD (C) and ICG/MSNs (D) using FMI. Black circles indicate the regions of interest for calculating the TBR at each time point. (E) Quantification of the fluorescence intensity at the tumour sites showing accumulation of ICG/MSNs-RGD. (F) Comparison of TBR profiles of the two probes. Experiments were run in triplicate.

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