Figure 4 | Scientific Reports

Figure 4

From: Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

Figure 4

(a,b) FACS cell cycle analysis indicated that there was a statistically significant difference between the OM-group (S phase: 49.53 ± 0.68%) and the FM-group (S phase: 55.40 ± 0.51%), P = 0.001, P < 0.05. The EV-group (S phase: 52.16% ± 0.71%) showed statistical significance when compared to the FM-group (P = 0.001, P < 0.05). There was a statistically significant difference between the EV-group and the OM-group, P = 0.04, P < 0.05. There was no statistically significant difference between the EV-group and the BM-group (S phase: 53.76 ± 0.50%), P = 0.073, P > 0.05), *P < 0.05, **P < 0.001. (c) The OD ratio of the FM-group is 1.12 ± 0.02, the BM-group (0.89 ± 0.05) and the EV-group (0.87 ± 0.04) were higher than that of the OM-group (0.80 ± 0.05) but lower than that of the FM-group. There was a statistically significant difference between the FM-group and the EV-group (P = 0.028, P < 0.05). There was a statistically significant difference between the OM-group and the FM-group (P = 0.025, P < 0.05). There was no significant difference between the EV-group and the OM group (P = 0.121, P > 0.05). There was no significance difference between the EV-group and the BM-group (P = 1.000, P > 0.05).

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