Figure 2: Effects of BDP on GR, PEPCK and blood glucose in fathead minnows.
From: Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish
(a) Relationship between PEPCK gene expression and increase of blood glucose in fish exposed to increasing plasma concentrations of BDP. Best-fit regression curves are shown for PEPCK gene expression measured in the liver (solid black curve) and blood glucose concentration (solid red curve). Effect magnitude was calculated for each individual sample as fold-changes versus the control mean value. (b) Highly significant correlations were observed between PEPCK and GR gene expression and (c) between PEPCK gene expression and blood glucose concentrations. The solid red line represents the linear regression curve, the dashed lines the 95% confidence interval.
