Figure 2
From: TLR5 mediates CD172α+ intestinal lamina propria dendritic cell induction of Th17 cells
MLN DC and LPDC take up and present CBir1 flagellin to T cells after mucosal challenge in vivo.
Wild-type and TCRβ×δ−/− mice were gavaged with Alexa 647-labeled CBir1 flagellin. Uptake of CBir1 flagellin by MLN DC and LPDC was determined 2 hrs later by flow cytometry (A). When cultured with CD4 T cells of CBir1 Tg mice, LPDC from CBir1-gavaged TCRβxδ KO, but not wild-type, mice stimulated T cell proliferation (B). Data are reflective of 3 independent experiments. *p<0.05 and **p<0.01 compared to controls.
