Table 1 The top10 upregulated and downregulated genes (p < 0.05) for H37Ra-infected versus control RAW264.7 cells at 24 h post infection as ranked by fold-change.

From: The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra

gene Symbol

gene name

log2 fold change

P-value

Csf3

colony stimulating factor 3 (granulocyte)

5.91

0

Gpnmb

glycoprotein (transmembrane) nmb

4.90

1.35E-167

Il1rn

interleukin 1 receptor antagonist

4.89

0

Atp6v0d2

ATPase, H+ transporting, lysosomal V0 subunit D2

4.54

2.78E-141

Cxcl2

chemokine (C-X-C motif) ligand 2

4.36

0

Il7r

interleukin 7 receptor

4.26

7.85E-68

Anpep

alanyl (membrane) aminopeptidase

4.09

7.14E-155

Ccl2

chemokine (C-C motif) ligand 2

3.90

0

Gdf15

growth differentiation factor 15

3.69

7.93E-50

Tgm2

transglutaminase 2, C polypeptide

3.66

1.66E-35

Cx3cr1

chemokine (C-X3-C motif) receptor 1

−3.00

2.17E-185

Fgd2

FYVE, RhoGEF and PH domain containing 2

−2.67

4.36E-33

Myh7b

myosin, heavy chain 7B, cardiac muscle, beta

−2.33

6.83E-11

Bmf

BCL2 modifying factor

−2.29

8.82E-16

Kirrel3

kin of IRRE like 3

−2.08

8.38E-14

Trem3

triggering receptor expressed on myeloid cells 3

−2.02

2.47E-10

Pi16

peptidase inhibitor 16

−2.02

8.16E-19

Gpr155

G protein-coupled receptor 155

−1.90

4.03E-07

Tnfsf13b

tumor necrosis factor (ligand) superfamily, member 13b

−1.85

1.06E-05

Sla

src-like adaptor

−1.85

7.93E-13