Figure 6 | Scientific Reports

Figure 6

From: Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment

Figure 6

Effects of Pygo2 knockdown by shRNAs on the recruitment of histone methyltransferase complex to the Wnt target genes promoters.

The core components of COMPASS-like complex, WDR5 and Ash2 on the promoters of Wnt/β-catenin pathway target genes in human brain glioma U251 (A,B) and U-87MG (D,E) cell lines were examined. The specific subunit of the MLL1/MLL2 histone methyltransferase (HMT) complex, menin (C,F) and specific subunits of SET-1 and MLL3/MLL4, CXXC1 (G,I) and NCOA6 (H,J), were also examined similarly. *P < 0.05 and **P < 0.01.

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