Table 2 Summary of the subgroup analysis results of NLR on OS and PFS/RFS.
Outcome | Variable | No. of studies | No. of patients | Model | HR (95%CI) | Heterogeneity | Meta-regression P value | |
|---|---|---|---|---|---|---|---|---|
Ph | I2(%) | |||||||
OS | All | 11 | 14250 | R | 1.38(1.22–1.56) | 0.002 | 64.1 | |
PCa type | 0.01 | |||||||
mCRPC | 7 | 3826 | F | 1.44(1.32–1.57) | 0.238 | 25 | ||
Localized PCa | 3 | 9715 | R | 1.16(0.98–1.36) | 0.109 | 54.9 | ||
All PCa | 1 | 709 | — | 1.55(0.97–2.47) | — | — | ||
Sample size | 0.19 | |||||||
>400 | 7 | 13409 | R | 1.32(1.16–1.49) | 0.005 | 67.8 | ||
<400 | 4 | 841 | F | 1.61(1.31–1.99) | 0.252 | 26.6 | ||
NLR cut-off | 0.756 | |||||||
≤3 | 6 | 4539 | R | 1.34(1.24–1.45) | 0.009 | 67.3 | ||
>3 | 5 | 9711 | R | 1.18(1.06–1.31) | 0.066 | 54.6 | ||
PFS/RFS | All | 9 | 12541 | R | 1.24(1.05–1.46) | 0.003 | 65.3 | |
Ethnicity | ||||||||
Asian | 3 | 1455 | F | 1.42(1.11–1.82) | 0.345 | 6 | ||
Caucasian | 6 | 11086 | R | 1.18(0.98–1.43) | 0.003 | 72.3 | ||
PCa type | ||||||||
mCRPC | 3 | 843 | F | 1.45(1.19–1.77) | 0.37 | 0 | ||
Localized PCa | 6 | 11698 | R | 1.16(0.97–1.39) | 0.01 | 66.6 | ||
Sample size | ||||||||
>400 | 5 | 11837 | R | 1.28(1.00–1.65) | 0.001 | 78.8 | ||
<400 | 4 | 704 | F | 1.14(0.98–1.33) | 0.255 | 26.1 | ||
NLR cut-off | ||||||||
≤3 | 6 | 3721 | F | 1.17(1.06–1.29) | 0.203 | 30.9 | ||
>3 | 3 | 8820 | R | 1.82(0.77–4.3) | 0 | 87.3 | ||
