Figure 5: Generation of unnatural haliangicin analogues in the gene-disrupted heterologous hosts.

HPLC analyses of extracts of the heterologous producer M. xanthus c10-11C/c7-6E (a), ΔhliR (acyl-CoA dehydrogenase disrupted host, (b), ΔhliD (O-methyltransferase-disrupted host, (c), and ΔhliU (epoxidase disrupted host, (d). The chromatograms were recorded at 290 nm.