Figure 3
From: Rab6a is a novel regulator of meiotic apparatus and maturational progression in mouse oocytes
Increased incidence of aneuploidy in Rab6a-siRNA oocytes.
(A) Chromosome spread of control and Rab6a-siRNA MII oocytes. Chromosomes were stained with Hoechst 33342 (blue) and kinetochores were labeled with CREST (purple). Representative confocal images indicate euploid control oocytes and aneuploid Rab6a-siRNA oocytes with 19 chromosomes and one chromatid (yellow arrowhead). (B) Quantification of aneuploidy in control and Rab6a-siRNA oocytes. 35 control oocytes and 30 Rab6a-siRNA oocytes were analyzed respectively. Error bars indicate ± SD. *p < 0.05 vs. controls.
