Figure 3: Analysis of differentially expressed (relative to Control) fetal ovarian genes following maternal sludge-exposure.
From: The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals
(a) More genes were altered following exposure in the 30–110T and 60–140T groups than in the 0–140T and 0–80T groups. Only probes that met an FDR of 5% and a threshold of ±0.7 on the log2 transformed fold change (LogFC) are displayed. For each exposure, probes were divided into categories according to their positive (yellow) or negative (blue) fold change. (b) Venn diagram depicting the number of differentially expressed transcripts by exposure group. Few differentially expressed transcripts were common to two or more periods of exposure. (c) Functional analysis of differentially expressed transcripts (FDR ≤5%; LogFC threshold ± 0.2) representing a number of specific biological pathways (d) was performed with Ingenuity Pathway Analysis (IPA) software. The few transcripts that were altered in the 0–80T group were excluded. Significance was computed by Fisher’s exact test and the horizontal blue line corresponds to the P-value threshold (P ≤ 0.05).
