Figure 4
Model evaluation results with independent external datasets from mice.
(A) Mice were intravenously injected with 5 × 105 MSCs22 (n = 5). (B–D) Mice were intravenously injected with 2 × 106 MSCs7 (n = 6). The solid line in each panel represents the concentration-time profile of the MSCs simulated by the PBK model while the closed circles represent measured biodistribution data. Concentration of the MSCs is expressed as number of cells per kilogram of tissue. The data are expressed as mean ± s.d. The initial concentrations for organs (0 cell/L) are not shown because a base-10 log scale is used for the concentration.
