Figure 6
Model evaluation results with independent external datasets from humans.
(A) The PBK model suggests that the time profiles of MSC concentration in liver significantly differ between patients after intravenous or intra-hepatic arterial injection of the same number (8.5 × 108) of MSCs. (B) Patients were intra-hepatic arterially injected with an average of 8.5 × 108 radiolabeled BMMCs26 (n = 8). (C,D) Patients were intra-hepatic arterially injected with an average of 3.2 × 108 radiolabeled MSCs for 24 hours and 10 days, respectively27 (n = 4). The residual radioactivity in the liver is expressed as the proportion of the whole body radioactivity. The solid line in each panel represents the concentration-time profile of the cells simulated by the PBK model while the closed squares represent measured biodistribution data. The data are expressed as mean ± s.d.
