Table 1 MSC-specific parameters used in the PBK model estimated by curve fitting.

From: A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells

Parameter (unit)

Description

Blood

Lung

Liver

Spleen

Kidney

Heart

Rest of body

P (unitless)

Partition coefficients

–

742.733

262.699

1633.24

305.351

3.097

6.765

Karrest (h−1)

Arrest rate constant

–

5.434

1.395

0.608

1.727

1.251

0.143

Krelease (h−1)

Release rate constant

–

0.108

0.066

0.856

0.054

0.016

0.957

Kdepletion (h−1)

Depletion rate constant

0.636

0.0589

0.060

0.002

0.151

0.039

0.148