Table 1 MSC-specific parameters used in the PBK model estimated by curve fitting.
Parameter (unit) | Description | Blood | Lung | Liver | Spleen | Kidney | Heart | Rest of body |
---|---|---|---|---|---|---|---|---|
P (unitless) | Partition coefficients | – | 742.733 | 262.699 | 1633.24 | 305.351 | 3.097 | 6.765 |
Karrest (h−1) | Arrest rate constant | – | 5.434 | 1.395 | 0.608 | 1.727 | 1.251 | 0.143 |
Krelease (h−1) | Release rate constant | – | 0.108 | 0.066 | 0.856 | 0.054 | 0.016 | 0.957 |
Kdepletion (h−1) | Depletion rate constant | 0.636 | 0.0589 | 0.060 | 0.002 | 0.151 | 0.039 | 0.148 |