Figure 7
Sequence alignment between Nef-SF2 and Nef-LAI.
(a) â–² indicates some residues differences between the two alleles in the N-terminal region and in Glu112 corresponding to Asp108 in Nef-LAI. The residues are coloured according to their physico-chemical properties (HKR in cyan, DE in red, STNQ in maroon, AVLIM in pink, FYW in blue, PG in orange and C in green). (b) Superimposition of Nef-LAI structure (in cyan) and Nef-SF2 structure (in brownish) shows that, while Nef-SF2 Glu112 might interact with the Nef-SF2 Arg109 due its longer side-chain, Nef-LAI Asp108 (shorter side-chain) could not be involved in an intramolecular salt bridge with Nef-LAI Arg105, remaining free to interact with ACOT8.
