Figure 6 | Scientific Reports

Figure 6

From: NAD+ regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent

Figure 6

NAD+ regulates Treg conversion into Th17 cells and promotes homeostasis through IL-10.

NAD+ promotes Tregs conversion into Th17 cells in absence of exogenous TGF-β and IL-6 cytokines after TCR engagement via purinergic receptors P2RX4 and P2RX7 and the transcription factors STAT3 and RORγt. Th17 cells differentiate in the presence of IL-2 and proliferate in absence of IL-23 cytokine. In addition, NAD+ promotes homeostasis via a robust systemic IL-10 originating from CD4+ T helper cells.

Back to article page