Table 3 Viral entry pathways of animal viruses and TMD lengths (predicted from hydrophobicity plots) of proteins known to play a key role in viral entry.

From: Transmembrane Domain Lengths Serve as Signatures of Organismal Complexity and Viral Transport Mechanisms

S. No.

Enveloped Virus (Protein)

Known* Entry Mode

Reference(s) for*

Predicted TMD Length(s)

Mean ± Std

1

HIV (gp41)

PM

33,45

30

28.25 ± 2.36

2

Herpes Simplex (Env glycoprotein gH)

33,45

28

3

Measles (Hemagglutinin)

33,45

30

4

Sendai (Fusion Protein)

33,45

25

5

Hepatitis C (E2 glycoprotein)

CME

29,30

17

10.80 ± 5.12

6

Sindbis (E1 glycoprotein)

28

5

7

Vesicular Stomatitis (Glycoprotein G)

31,32

7

8

Semliki Forest (E1 glycoprotein)

33

15

9

Equine Infectious Anemia (Outer membrane protein)

34

10

10

Vaccinia (A21 protein)

MPE

33,46

8

20.67 ± 7.06

11

Filamentous Influenza (Hemagglutinin)

38

27

12

Cytomegalovirus (Env Glycoprotein H)

37

20

13

Respiratory Syncytial virus A (F1 protein)

36

27

14

African Swine Fever (177L)

35

19

15

Ebola (Envelope Glycoprotein)

39, 40, 41

23

16

SV 40 (Agnoprotein)

CAME

43

10

13.75 ± 7.50

17

Polyoma (Agnoprotein)

43

10

18

New Castle Disease (F1 protein)

42

25

19

Echovirus 1 (Capsid protein)

44

10

  1. PM – Plasma membrane; CME – Clathrin-mediated endocytosis; MPE – Macropinocytosis; CAME – Caveolin-mediated endocytosis.
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