Table 4 Arteriolopathy after CsA treatment for 7 weeks.

From: Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats

Treatment groups

N

Grade of arteriolopathy due to CsA nephrotoxicity

No. of positive cases

P value

VHa

6

Absent to mild

6

 < 0.01a

Moderate to severe

0

CsAa,*

8

Absent to mild

0

Moderate to severe

8

CsA + M

6

Absent to mild

0

 

Moderate to severe

6

CsA + L(100mg/L) + M*

4

Absent to mild

2

 < 0.05*

Moderate to severe

2

  1. N; number of subjects, VH; vehicle (olive oil), M; mizoribine, L; losartan.
  2. CsA; cyclosporine A, Score of arteriolopathy due to chronic CsA toxicity (0: none, 1: rare and non-circumferential, 2: frequent and non-circumferential, 3: circumferential).
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