Figure 7: Effects of SJ and FSJ on hippocampal neurogenesis and cognitive function under normal conditions. | Scientific Reports

Figure 7: Effects of SJ and FSJ on hippocampal neurogenesis and cognitive function under normal conditions.

From: Fermented Sipjeondaebo-tang Alleviates Memory Deficits and Loss of Hippocampal Neurogenesis in Scopolamine-induced Amnesia in Mice

Figure 7

(A) The cross-over latency time is shown for the passive avoidance test. (B) The latency time to find the hidden platform is shown for the spatial reference learning and memory test that was performed for 6 days. The values shown are means ± SEM (n = 6). (C) Representative images are shown that indicate proliferation or survival of newly-generated cells in the DG of the hippocampus for CON-treated, 500 mg/kg SJ-treated, or FSJ-treated mice. The scale bar = 100 μm. The graph shows the number of BrdU-positive cells in the proliferation and the survival group. Data are presented as the mean ± SEM (n = 5 mice/group). (D) The level of BDNF, level of ACh, and AChE activity in hippocampus tissue homogenates from CON-treated, 500 mg/kg SJ-treated, or FSJ-treated mice were determined. Data are presented as the mean ± SEM (n = 6–8 mice/group).

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