Figure 2: Gene ontology, canonical pathway and network analysis.
From: Regulation of global gene expression and cell proliferation by APP
(A) Significantly affected GO categories (black bar) and subcategories (white bar) of biological process are plotted, p < 0.05 by DAVID. (B) Significantly affected GO categories (black bar) and subcategories (white bar) by upregulated genes are plotted, p < 0.05 by DAVID. (C) Significantly affected GO categories (black bar) and subcategories (white bar) by downregulated genes are plotted, p < 0.05 by DAVID. (D) Canonical pathway analysis was performed by using IPA. 13 significant affected pathways are generated, p < 0.05 (-log p-value > 1.30). According to the functional and biological connectivity, 25 networks are constructed by IPA. Two of top ranked networks, (E) RNA post-transcriptional Modification/Cancer/Cell Cycle network and (F) nucleic acid metabolism/small molecule biochemistry/genetic disorder network, generated by IPA are presented. Red and green colored genes represent up- and downregulated genes, respectively. Solid lines and dash lines denote direct or indirect interactions, respectively.
