Figure 4: Myocardial morphology, biometrics and interstitial fibrosis in hearts from young or old WT and MIF−/− mice. | Scientific Reports

Figure 4: Myocardial morphology, biometrics and interstitial fibrosis in hearts from young or old WT and MIF−/− mice.

From: Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation

Figure 4

(A–D) Representative FITC-conjugated Lectin immunostaining depicting transverse sections of left ventricular myocardium (×400) in young or old WT and MIF−/− mice; (E–H) Representative Masson Trichrome staining depicting interstitial fibrosis of myocardium (×400) in young or old WT and MIF−/− mice; (I) Quantitative analysis of cardiomyocyte cross-sectional area; (J) Heart weight-to-body weight ratio; and (K) Quantitative analysis of interstitial fibrosis. Mean ± SEM, n = 6 mice per group for panels I and K, 11–12 mice per group for panel (J), *p < 0.05 vs. WT young group, #p < 0.05 vs. WT old group.

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