Figure 1

Intrinsic functional connectivity of three seeds in brain regions previously demonstrated to play a role in self-referential cognition.

(A) Representation of location of the three seeds (10 mm diameter) with identifying color and number: 1. MPFC = red, 2. CP = blue, 3. CACC = green. Seed location is based on a meta-analysis of self-referential cognition¹⁵. For confirmation that these regions are important for self-cognition, we queried the Neurosynth database with the search term “self” (http://neurosynth.org)⁴⁴. This resulted in the yellow activation map (thresholded at z-value >4.0). Substantial overlap between the seed regions and the Neurosynth map is apparent. (B) Brain surface maps illustrating regions with significant intrinsic functional connectivity with each of the three seed regions. Areas showing connectivity to Seeds 1, 2 and 3 are shown in red, blue and green, respectively. Overlap between Seed 1 and Seed 2 is shown in purple. All results are whole-brain FWE cluster-level corrected at p < 0.05 after setting the voxel-level uncorrected threshold to p < 0.001. n = 35; LH = Left hemisphere; RH = Right hemisphere.