Figure 1: SIRT3 deletion decreased bone mass in vivo.
From: Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice
(a) Microcomputed tomography (μCT) images of the tibias of 8-week-old wild type (WT) and Sirt3−/− mice (Left), and quantification of trabecular bone volume and architecture (Right). BV/TV, bone volume per tissue volume; Tb.Th, trabecular thickness; Tb.Sp, trabecular spacing; Tb.N, trabecular number. n = 5 per group. *P < 0.001. Scale bar, 1 mm. (b) Quantification of osteoclasts and osteoblasts form histological analysis of tibias of WT and Sirt3−/− mice. N.Oc/BS, osteoclast number per bone surface; N.Ob/BS, osteoblast number per bone surface. n = 6 per group. *P < 0.05. Data represent mean ± SD.
