Figure 2: Gold standard network depicting direct regulatory relations in S. cerevisiae.

Larger circles represent transcription factors, smaller circle represent genes. Blue circles represent transcription factors of interest, whereas green circles represent their local causal networks. All other transcription factors and genes are colored in grey. Direct edges represent direct regulatory relations. Edges connecting transcription factors of interests and their local causal pathways are colored in black. All other edges are colored in grey. The goal of the study is to discover the edges shown with black from observational data and limited experiment.