Table 3 Ki-values for different inhibitors.
From: A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
inhibitor | Enzyme | Ki (3) [μM] | Ki (NAD+) [μM] |
|---|---|---|---|
NAM | Sirt3 | 93.0 ± 8.5 | 45.0 ± 14.2 |
Sirt6 | 451.0 ± 60.7 | 415.0 ± 45.1 | |
Ex-527 | Sirt6 | 100.0 ± 11.0 | n.d. |
Quercetin | Sirt6 | 21.0 ± 3.4 | n.d. |
S2iL5 | Sirt2 | 0.6 ± 0.2 | n.d. |
8 | Sirt2 | 0.08 ± 0.02 | n.d. |
Sirt3 | 0.1 ± 0.02 | n.d. | |
Sirt6 | 0.4 ± 0.1 | n.d. | |
Sirt6 a | 1.1 ± 0.1 e | n.d. | |
Sirt6 b | 1.9 ± 0.2 e | n.d. | |
9 | Sirt6 c | 0.6 ± 0.1 e | n.d. |
Sirt6 d | 1.7 ± 0.5 e | n.d. | |
10 | Sirt2 | 0.3 ± 0.1 | n.d. |
11 | Sirt2 | 50.0 ± 9.9 | n.d. |
