Figure 1
Candidate TM-targeting peptide sequences identified during direct in vivo ME phage screening.
(A) Peptide sequences expressed by bacteriophage recovered from the ME, 1-hr after exposure of the TM. Different colors represent amino acids (aa) with similar characteristics; Blue are basic aa, red are acidic aa, orange are aromatic aa, yellow are sulfur containing aa, polar hydroxylic aa are light red, polar amidic aa are light blue and green is proline. (B) Sequence alignment of the different recovered phage peptides showing a phylogenetic family division. The peptides fall into two phylogenetic families based on amino acid characteristics. (C) Frequency of occurrence (Logo plot) of the different amino acids in the phage display selected ligands from Strategy 1.
