Figure 1: Photodynamic killing of cancer cells by complex 1.
From: Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand
(A) Structure of complex 1. (B) Survival fractions of HeLa cells following exposure to increasing doses of complex 1. Cells were pre-treated with complex 1 prior to 3 min exposure to 405 nm light (3.6 J cm−2). (C) Survival fractions of HeLa cells exposed to light in the absence of complex 1. (D) Survival fractions of cervical cancer (HeLa), colorectal cancer (SW480), bladder cancer (EJ) and cisplatin-resistant bladder cancer (EJ-R) cells. Cells were pre-treated with 400 nM complex 1 prior to 3 min exposure to 405 nm light. Data shown are mean and standard deviation of at least 3 independent experiments. Significance was determined using the Student’s T-test where n = 3 and p < 0.01 is indicated by **, and p < 0.05 is indicated by *. Survival fractions were calculated relative to untreated control.
