Figure 2 | Scientific Reports

Figure 2

From: HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q

Figure 2

Telomere and iciHHV-6A analysis in the lymphoma and blood DNAs.

(a) An example STELA blot showing amplified telomere molecules at iciHHV-6A (DR1R primer), 12q, 17p and XpYp in the pleural fluid (1500-T). (b) Scatter plots of the compiled 1500-T telomere length data showing median length and inter-quartile ranges. (c) PCR-based truncation assay using the UDL61R primer in STELA in the patient’s blood (1500-Bl) or pleural fluid (1500-T) and in DNA from the two brothers (1499 and 1501). The arrow shows the expected location of DRL-T2 truncation products (d) Amplification with U100Fw2 and UDL61R primers generated products (grey arrow head) in the DNA from brother 1501. These amplicons show the presence of low abundance extra-chromosomal circular HHV-6A molecules.

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