Table 1 Mutation analysis of VDJ region in Mef−/−Rad50s/s plasma cell tumor samples.

From: Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Mice UID

Tumor

VH

DH

JH

No.Mutations

at VH

Mutations at

VH and

Amion Acid Changes

Percent Mutations

at VH

33

MM

IGHV1-50*01, IGHV1-59*01 or IGHV1S40*01

IGHD2-3*01

IGHJ4*01

1

c227 > g, A76 > G

1.0

112

MM

IGHV1-67*01

IGHD4-1*01

IGHJ3*01

2

c227 > g, A76 > G a232 > t, M78 > L

2.1

217

PCT

IGHV1-67*01

IGHD3-2*02

IGHJ3*01

7

c227 > g, A76 > G

7.3

a232 > t, M78 > L

g25 > c, S85 > T

a256 > t, T86 > S

a263 > t, Y88 > F

a290 > g, E97 > G

g291 > a, E97 > G

  1. The first two columns show mouse UID and the phenotype of the mice (MM, multiple myeloma; PCT, solitary plasmacytoma). The VH, DH, and JH usage and mutations were scored by comparing each sequence with the germline sequences at the IMGT server.
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