Figure 5: StoS and SreKRS overlapping signalling circuits.

(A) Venn diagram showing that more than half of the differential expressed proteins in PXOΔstoS and PXOΔsreK overlap. (B) The differentially expressed proteins in PXOΔstoS and PXOΔsreK compared with the wild-type strain PXO99A are shown together in a scatter diagram. (C) Relative expression levels of StoS and SreK in PXOΔstoS and PXOΔsreK compared with the wild-type strain PXO99A identified by iTRAQ. (D) mRNA abundance of stoS and sreK in PXOΔstoS and PXOΔsreK compared with the wild-type strain PXO99A. The dotted lines indicate critical 1.5-fold up- or down-regulation. *denotes a statistical difference in which P ≤ 0.05, and **denotes P ≤ 0.01. (E) The relationship between StoS and SreKRS. Results of using StoS and SreKRS as queries in the STRING database. Lines in different colours represent special relationships between two proteins. PXO_03023, methyltransferase; PXO_06172, response regulator; PXO_03077 /PXO_03076, hypothetical protein; PXO_03020, transcriptional regulator NtrC family; PXO_02019, putative signal protein with GGDEF domain; PXO_00994, response regulator.