Figure 1 | Scientific Reports

Figure 1

From: A “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities

Figure 1

(A) The helical wheel projection of peptide Jp-Hp and Jp-GGG-Hp, with hydrophobic residues shaded. (B) Predicted 3D structures of Jp-Hp and Jp-GGG-Hp. The calculation of 3D structure was based on the web tool at: http://bioserv.rpbs.univ-paris-diderot.fr/PEP-FOLD/; (C) is the 3D structure of selected peptides, where the possible intramolecular interactions between the guanidinium group of argnine and the indole ring of tryptophan were observed in peptides C20-Jp-Hp (I) and C20-Hp-Jp (III), while these interactions were absent in other peptides. For all peptides in (A–C), the number of I to VI refers to peptides Jp-Hp (I), Jp-GGG-Hp (II), Hp-Jp (III), Hp-GGG-Jp (IV), ALLSA-Hp (V) and Hp-ALLSA (VI), respectively.

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