Figure 5
From: Selective advantage of trisomic human cells cultured in non-standard conditions
Aneuploidy favors proliferation of non-transformed amniotic fibroblasts grown under non-standard conditions.
The graphs show growth curves for AF and AF + 13 cells cultured for six days under different conditions (treatment starting at day 0). Data for cells cultured in standard media (A), serum-free media (B), or media containing 5 μM 5-FU (C) are reported as mean and standard deviations from 2–3 biological replicates. For statistical analysis, the growth curves in logarithmic scale were fit to linear functions and analyzed using R software package. The numbers to the right of the graphs indicate the p values for comparison of end-point data. Statistical analysis was also performed on the trends in cell growth using the geepack R package for longitudinal data analysis60 and showed statistically significant difference for all pairwise comparisons (Standard, p = 0.02; Serum-free and 5-FU, p < 1E-6).
