Figure 6
From: Interleukin-31 expression and relation to disease severity in human asthma
Immunohistochemical analysis of IL-31.
Bronchial tissue obtained from healthy subjects (n = 5) and asthmatic patients (n = 9) who underwent fibreoptic bronchoscopy was processed immunohistochemically to show tissue IL-31 expression. Specific staining for IL-31 is brown (red arrows), whereas nuclei are stained blue (Magnification × 400). Representative photomicrographs are presented from (A) a healthy individual and (B) a patient with mild asthma and (C) patient with severe asthma and (D) the corresponding isotypic control. The expression of IL-31 in patients with severe asthma were higher than those in controls and paitents with mild asthma (E) Moreover, the percentage (%) of cells expressing IL-31 correlated positively with serum IL-31 levels (r = 0.60; p = 0.022, (F)) and BALF IL-31 levels (r = 0.61; p = 0.019, (G)). Data are presented as median with interquartile range. *p < 0.05, **p < 0.01.
