Figure 1: miR-155 deletion prevents HFD-induced obesity in female mice, and WAT accumulation in females and males.
From: miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
(a) Female miR-155 KO mice are protected against HFD-induced obesity. The body weight (BW) of female miR-155 KO mice on HFD was not significantly different from KO mice on CD, and was 56% lower than WT mice on HFD. (b) Percent BW gain from start of experiment in female WT and miR-155 KO mice on CD or HFD. (c) Percent BW difference between HFD/CD animals shows that HFD caused 35% less weight gain in KO mice. (d) Compared to WT mice on HFD, female miR-155 KO mice on HFD had lower final WAT mass. (e–g) For males, both WT and miR-155 KO mice on HFD gained significantly more BW than respective CD controls. (h) Compared to WT mice on HFD, miR-155 KO male WAT weight was reduced. * indicates p < 0.05.
