Figure 3: miR-155 deletion in females abrogated HFD-induced WAT adipocyte hypertrophy.
From: miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
(a) Representative images show hematoxylin-eosin-stained WAT from WT and miR-155 KO female mice fed either CD or HFD. In WT mice, HFD increased average adipocyte cross-sectional diameter by 61%. In miR-155 KO mice, the effect of HFD on adipocyte size was abolished. The histogram that displays different adipocyte diameters demonstrates reduced KO adipocyte size. Scale bar = 100 μm. (b) In intrascapular BAT, brown adipocyte diameter and morphology was not significantly altered by miR-155 deletion or by HFD. Hematoxylin and eosin were used to visualize BAT cytoarchitecture. Data were analyzed using overall average diameter and by measuring percent area of fat globules. Scale bar = 50 μm. * indicates p < 0.05.
