Figure 5: Transplant of miR-155 KO bone marrow (BM) into female WT host mice conferred limited obesity resistance.
From: miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
(a,b) Compared to control mice receiving WT bone marrow (WT-BM) transplant, chimeric mice that received miR-155 KO bone marrow (KO-BM) were partially protected from HFD-induced weight gain. (b) Percent body weight gain shows that HFD elicits 50% less weight gain in KO-BM mice. (c) WAT weight was not significantly altered in mice with miR-155 KO BM. (d) After overnight fast, mice with WT-BM or KO-BM lost similar percent body weight. (e) Glucose tolerance was not different between the two chimeras. (f) After insulin injection, chimeras with either WT or KO BM responded similarly. * indicates p < 0.05.
