Figure 2

Differential effects of LPS on microglial activation and DA neuron loss in the SN of female and male mice.

(a,d) Representative immunostained micrographs show Iba1⁺ (a) and TH⁺ (d) cells in the SN of female and male mice 1 day after an LPS (0.15 mg/kg of body weight, i.p.) injection. Scale bar: 10 μm in (a); 200 μm in (d). Quantitative results of Iba1⁺ cell areas (b), the number of Iba1⁺ cells (c) and the number of TH⁺ cells (e) in the SN of female and male mice 1 day after an LPS injection (n = 5–6). **(p < 0.01), ***(p < 0.001): versus the respective Saline control.