Figure 6
From: Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel
Effects of 17β-estradiol (E2) on LPS-induced inflammation in the BV2 microglial cells.
The production of TNF-α in the BV2 cells given E2 30 min before (a, Pre-treatment), together (b, Co-treatment) and 30 min after (c, Post-treatment) the LPS treatment (n = 4). **(p < 0.01), ***(p < 0.001): versus respective Saline controls. ###(p < 0.001): versus no E2 treatment (0) group. Effects of E2 pre-treatment on LPS-induced elevations of TLR4 (d) and p-p38 (e). Representative immunoblots are shown in the upper panels and quantitative data in the respective lower panels. (n = 3). **(p < 0.01), ***(p < 0.001): versus respective Saline group. ##(p < 0.01), ###(p < 0.001): versus respective Vehicle (Veh) control group.
