Figure 1: Luciferase activities of the haplotypes or genetic variants of OCTN2 promoter region.

The promoter activities were measured 48 hours after transient transfection of the reporter plasmids containing the major OCTN2 haplotypes (a) or genetic variants (b) into HCT-116 cells. Then, the luciferase activity of each construct was compared with that of the reference (REF, H1). The data (mean ± SD) were obtained from triplicate wells. **P < 0.01, ***P < 0.001 vs. reference promoter activity.