Table 1 Cytokine profile induced by EMD- and controlled-operated sites during early periodontal wound healing.

From: EMD in periodontal regenerative surgery modulates cytokine profiles: A randomised controlled clinical trial

 

Day 7

Range day 7

Day 14

Range day 14

EMD

↑Total protein

5227.14

↑Total protein

4362.86

↓TGF-α#

0.03

↓TGF-α#

0.05

↓IFN-γ

0.01

↑IFN-γ

0.01

↑MDC

0.01

↑MDC

0.20

↓IL-4

0.03

↑IL-4

0.03

↑IL-6#

0.40

↑IL-6#

0.21

↑IL-8#

3.80

↑IL-8#,*

1.18

↑PDGF-AA

0.02

↑PDGF-AA

0.06

↓PDGF-BB

0.12

↓PDGF-BB*

0.12

↓IP-10

0.03

↑IP-10

0.14

↑MCP-1

0.05

↑MCP-1

0.06

↑TNF-α#

0.02

↑TNF-α

0.08

↓VEGF

0.15

=VEGF

0.38

CONTROL

↑Total protein

6400.00

↑Total protein

5531.43

↓TGF-α#

0.05

↓TGF-α#

0.06

↓IFN-γ

0.01

↑IFN-γ

0.04

↑MDC

0.02

↑MDC

0.21

↓IL-4#

0.03

↑IL-4

0.10

↑IL-6#

0.51

↑IL-6#

0.11

↑IL-8#

2.12

↑IL-8#,*

0.94

↑PDGF-AA

0.05

↑PDGF-AA

0.16

↓PDGF-BB

0.10

↑PDGF-BB*

0.25

↓IP-10#

0.04

↑IP-10

0.27

↑MCP-1

0.03

↑MCP-1

0.03

↑TNF-α#

0.08

↑TNF-α#

0.03

↓VEGF

0.24

↑VEGF

0.71

  1. Cytokines after symbol ↑, ↓ or = mean that they are increased, decreased or constant respectively based on mean values of fold changes compared to baseline cytokine levels. Total protein values are given in μg ml−1. Cytokine levels are given in pg cytokine μg total protein−1. The range is calculated from changes with respect to baseline levels. Only statistically significant changes marked with * or # define whether a cytokine is changed. #Significant intra-group differences compared to baseline cytokine levels (p < 0.05). *Significant inter-group differences at day 7 or day 14 (p < 0.05) (n = 12 patients).
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