Figure 3
From: Functional Genome Screening to Elucidate the Colistin Resistance Mechanism
(A) PCR amplification of MrgS gene; (B) Growth profile of host, host with vector only and host with MrgS gene on colistin plate; (C) Domains of the MrgR/MrgS two component system and positions of all mutations in MrgS gene comferring colistin resistance. MrgS domains, “HisKA” - Histidine Kinase A dimerization/phosphoacceptor domain; “HATPase_c” - Histidine kinase-like ATPases. (D) Proposed model showing the activation of lipopolysaccharide-modifying genes involved in colistin resistance.
